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Literature summary extracted from

  • Casals, N.; Buesa, C.; Marrero, P.F.; Belles, X.; Hegardt, F.G.
    3-Hydroxy-3-methylglutaryl coenzyme A synthase-1 of Blattella germanica has structural and functional features of an active retrogene (2001), Insect Biochem. Mol. Biol., 31, 425-433.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.3.10 intronless gene, encodes for an active enzyme able to complement eukaryotic Mev-1 cells Blattella germanica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Blattella germanica mevalonate pathway (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
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Organism

EC Number Organism UniProt Comment Textmining
2.3.3.10 Blattella germanica
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 cockroach
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.10 embryo
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 Blattella germanica
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
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 Blattella germanica (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
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 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O mevalonate pathway Blattella germanica (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
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 ?
2.3.3.10 additional information first organism known to have 2 functional cytosolic HMG-CoA synthases Blattella germanica ?
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 ?